2025 MLB All-Star Game odds, line, prediction, time: AL vs. NL picks from MLB expert on 182-110 run

The American League will look to make it two wins in a row and 11 of the last 12 when they battle the National League in the 2025 MLB All-Star Game on Tuesday. The AL won last year’s game 5-3, after the NL had snapped a nine-game losing streak in 2023. The AL holds a 48-44-2 all-time edge over the NL in the all-time series. In 94 games, the American League has outscored the National League 388-380. Paul Skenes (4-8, 2.01 ERA) will start for the NL, with Tarik Skubal (10-3, 2.23 ERA) on the hill for the AL.

First pitch from Truist Park in Atlanta is set for 8 p.m. ET. Since 1997, the AL has gone is 22-4-1. The National League is a -115 favorite on the money line (risk $115 to win $100) in the latest 2025 MLB All-Star odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 7. Before making any American League vs. National League picks, be sure to see the 2025 MLB All-Star Game predictions from SportsLine’s Matt Severance.

Severance is a well-connected writer and handicapper who has worked in the industry since 2005. Over his past 293 MLB picks, he has gone 182-110-1 and is up $1,003. Anybody following at sportsbooks and on betting apps could have seen strong returns.    

Now, Severance has set his sights on American League vs. National League. You can visit SportsLine now to see his picks. Here are the MLB odds and betting lines for the MLB All-Star Game 2025, which you can get in on with a DraftKings promo code or a FanDuel promo code.

Why the National League can win

Los Angeles Dodgers designated hitter Shohei Ohtani, who is leading off on Tuesday, continues to be among MLB’s top hitters. In 95 games this season, he is hitting .276 with 12 doubles, seven triples, 32 homers, 60 RBI and 12 stolen bases. He has hits in five of his last eight games. In a 9-1 loss at Milwaukee on July 7, he was 2-for-4 with one run scored.

Atlanta Braves outfielder Ronald Acuna Jr. is among baseball’s top hitters, and he should be motivated to perform in front of the home crowd. In 45 games this season, he is batting .323 with seven doubles, 12 homers and 22 RBI. In a 6-5 win at St. Louis on Friday, he was 3-for-5 with two doubles and one RBI. He was 2-for-4 with two homers and two runs scored in a 9-2 win over the Athletics on Wednesday. See which team to back at SportsLine.

Why the American League can win

Seattle catcher Cal Raleigh leads MLB with 38 home runs so far this season and is coming off a win in the Home Run Derby. He has seven multi-homer games in 2025. In 94 games this season, he is hitting .259 with 16 doubles, 82 RBI and 10 stolen bases. In Friday’s 12-3 win at Detroit, he was 2-for-5 with two homers and five RBI.

New York Yankees outfielder Aaron Judge leads all of MLB in batting, hitting .355. In 96 games, he has 24 doubles, two triples, 35 homers and 81 RBI. In Saturday’s 5-2 loss to the Chicago Cubs, he was 3-for-4 with two doubles, one homer and two RBI. He was 2-for-5 with a homer and two runs scored in a 10-3 win over the Seattle Mariners on July 8. See which team to back at SportsLine. 

How to make 2025 MLB All-Star Game picks

Severance is leaning Under on the total and has identified a critical x-factor that has him backing one side. See who it is at SportsLine.

Who wins the 2025 MLB All-Star Game, and what critical x-factor do you need to know about? Visit SportsLine right now to get Severance’s picks, all from the MLB handicapper who is 182-110-1 and is up $1,003 in his last 293 MLB picks.