Most biologists who study pathogenic microbes have focused on strains such as Escherichia coli or Staphylococcus aureus, which are not only important for human health, but also relatively easy to grow in the lab.
Rebecca Lamason, an MIT associate professor of biology, wants to take a more expansive approach that includes bacteria that are more challenging to study. Tackling those microbes, she says, can help scientists learn more about the huge diversity of strategies that pathogens have evolved to interact with their hosts.
In her lab, she has devised new tools for analyzing pathogens such as Rickettsia parkeri, a tickborne bacterium that causes a mild form of spotted fever. She also studies Listeria monocytogenes, a microbe commonly linked to foodborne illnesses.
From studying these microbes, she hopes to learn more about the many strategies that pathogens have devised to take over host cell machinery, which also offers insight into the fundamental functions performed by those host cells.
“We cannot learn everything from a single type of bacterium or a single type of cell,” Lamason says. “There’s a rich diversity of biological mechanisms that are out there, and I think we have just barely scratched the surface on that.”
In just one recent example, her lab found that R. parkeri can form very tight connections with a cell structure called the endoplasmic reticulum (ER), which mimics some of the interactions that the host cell’s own organelles have with the ER. They’re still puzzling out the reason for this interaction, which hasn’t been seen with other microbes.
“It’s one of those things too where we had gone into the microscope room to look at something else to ask a different question, and we discovered this other unexpected interaction,” Lamason says. “This has been a really fun experience, and it’s also very common when you’re doing cell biology experiments: you see some phenomenon that you didn’t expect.”
How systems interact
As a high school student, Lamason was drawn to cell biology and physiology, and she decided she wanted to pursue a PhD even before she knew exactly what that career path would look like.
“I didn’t have anybody in my family that had a PhD or worked in science, and so I didn’t really know what it took or what it was to get a PhD, but for some reason I wanted to do it,” she says.
Her father was in the military, so her family moved quite a bit, mainly between Florida, California, and Virginia, before settling in Pennsylvania. After graduating from high school, where she was the editor-in-chief of the school newspaper, Lamason spent two years at a local community college before transferring to Millersville University to finish her bachelor’s degree.
At Millersville, she majored in molecular biology and biotechnology and worked in a lab studying chlorella viruses, which infect algae.
“We were characterizing different variants that we could isolate from a pond that was next to the building, so we were looking at very simple questions, but that experience allowed me to see what it was like to ask questions, what it was like to work regularly in a lab,” she recalls.
